Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 42, Pages 15078-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja904670x
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Funding
- American Heart Association
- NSF [CHE-0848397]
- Ohio Board of Regents
- KSU GSS
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0848397] Funding Source: National Science Foundation
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We report a kinetic study of the reaction between superoxide and an important intracellular form of vitamin B-12, cob(II)alamin. Superoxide is implicated in the pathophysiology of many inflammatory diseases, whereas vitamin B,2 derivatives are often beneficial in their treatment. We found that cob(II)alamin reacts with superoxide at rates approaching those of superoxide dismutase itself, suggesting a probable mechanism by which vitamin B-12. protects against chronic inflammation and modulates redox homeostasis.
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