Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 47, Pages 15760-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja805634x
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Funding
- NIH [R01 EB005288]
- University of Utah Research Foundation [51003289]
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Enzyme-based hybrid hydrogels were prepared by covalently incorporating an adenylate kinase mutant, possessing two thiol groups, into HPMA copolymer- or PEG-based hydrogel structures. The nanoscale conformational change of enzyme, triggered by substrate recognition, translated into macroscopic motion of hydrogels.
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