4.8 Article

Smart Hydrogels Containing Adenylate Kinase: Translating Substrate Recognition into Macroscopic Motion

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 47, Pages 15760-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja805634x

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Funding

  1. NIH [R01 EB005288]
  2. University of Utah Research Foundation [51003289]

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Enzyme-based hybrid hydrogels were prepared by covalently incorporating an adenylate kinase mutant, possessing two thiol groups, into HPMA copolymer- or PEG-based hydrogel structures. The nanoscale conformational change of enzyme, triggered by substrate recognition, translated into macroscopic motion of hydrogels.

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