Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 22, Pages 6896-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja710321g
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Funding
- NEI NIH HHS [EY017568, R21 EY017568] Funding Source: Medline
- NIAID NIH HHS [R01 AI045297, P30 AI050410-08, P30 AI050410, AI045297, AI50410, R56 AI045297, R01 AI045297-10] Funding Source: Medline
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The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. eSDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721) -gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.
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