Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 47, Pages 15808-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja8039585
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Funding
- National Nature Science Foundation of China [20536050, 20221603, 20636010]
- Chinese Academy of Sciences [KJCX2-YW-M02]
- Knowledge Innovation Program
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One-pot approach to couple the crystallization of CaCO3 nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
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