Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 11, Pages 3304-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja710555g
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This communication describes the Pd(OAC)(2)-catalyzed ethoxycarbonylation reactions of aromatic C-H bonds using dietho azodicarboxylate (DEAD) together with Oxone or K2S2O8. Substrates such as 2-arylpyridines, pyrrolidinone, acetylindoline, quinoline, and oximes were ethoxycarbonylated with excellent chemo- and regioselectivities. The catalytic reaction is probably initiated by chelation-assisted cyclopalladation of the ortho C-H bond. Preliminary studies suggested that reactive ethoxyacyl radicals generated from thermal decomposition of DEAD were involved in the ester formation.
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