4.8 Article

Structural basis of DNA quadruplex recognition by an acridine drug

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 21, Pages 6722-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja8016973

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Funding

  1. Cancer Research UK [C129/A4489] Funding Source: Medline

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The crystal structure of a complex between the bimolecular human telomeric quadruplex d (TAGGGTTAGGGT)(2) and the experimental anticancer drug BRACO-19, has been determined, to 2.5 angstrom resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands.

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