Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 20, Pages 6320-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja801339w
Keywords
-
Categories
Funding
- NCI NIH HHS [CA122648, R21 CA122648, R21 CA122648-01A1, R21 CA122648-02S1, R21 CA122648-02] Funding Source: Medline
- NIGMS NIH HHS [R01 GM066137-04, R01 GM066137-01, R01 GM066137-04S1, R01 GM066137-06, R01 GM066137-02, R01 GM066137-05A1, R01 GM066137, R01 GM066137-03, GM066137] Funding Source: Medline
Ask authors/readers for more resources
In this communication, we report a simple, but highly adaptable, method of constructing selective target-responsive hydrogels using DNA aptamers. The simplicity of the design is accomplished by using linear polymer chains as the hydrogel backbone and a DNA aptamer as the cross-linker. in this design, competitive binding of target to the aptamer causes the decrease of cross-linking density and, hence, dissolution of the hydrogel. The adaptability of this strategy for therapeutic applications was demonstrated using two different types of targets, small molecules and proteins. Our results indicated that this molecular engineering provides a highly selective and controllable release system whereby efficient release of therapeutic agents can occur at specific environments in which the target biomarker is found.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available