Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 29, Pages 9186-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja801482d
Keywords
-
Categories
Funding
- NCI NIH HHS [U54 CA119342, N01CO37007, U54 CA136398-010003, U54 CA119342-040001, CA119342, U54 CA136398] Funding Source: Medline
- NHLBI NIH HHS [HL073646, R01 HL078631-04, R01 HL078631-03, R01 HL078631-01, R01 HL078631, R01 HL078631-02, R01 HL073646] Funding Source: Medline
- NIAID NIH HHS [N01CO37007] Funding Source: Medline
- NINDS NIH HHS [R01 NS059302-01, R01 NS059302, NS059302, R01 NS059302-02] Funding Source: Medline
Ask authors/readers for more resources
Although gadolinium has been the dominant paramagnetic metal for MR paramagnetic contrast agents, the recent association of this lanthanice with nephrogenic systemic fibrosis, an untreatable disease, has spawned renewed interest in alternative metals for MR molecular imaging. We have developed a self-assembled, manganese(III)-labeled nanobialys (1), a toroidal-shaped MR theranostic nanoparticle. In this report, Mn(III) nanobialys are characterized as MR molecular imaging agents for targeted detection of fibrin, a major biochemical feature of thrombus. A complementary ability of nanobialys to incorporate chemotherapeutic compounds with greater than 98% efficiency and to retain more than 80% of these drugs after infinite sink dissolution, point to the theranostic potential of this platform technology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available