Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 15, Pages 5286-5292Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja710934v
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Funding
- NCI NIH HHS [R01 CA131797-02, R01 CA131797] Funding Source: Medline
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Multiplexed nanobarcodes have been prepared with quantum dots (QDs) and alternating amphiphilic copolymers consisting of hydrocarbons and maleic anhydride groups. In homogeneous solution, the QD-polymer complexes grow epitaxially into nanobeads of narrow size dispersity, which has been previously achieved only for micrometer-sized beads in the presence of solid supports. As a result of this new nanostructure formation mechanism, more than 250 QDs can be loaded into a nanobead of 100 nm in diameter. A model assay for sensitive detection of human prostate specific antigen has also been demonstrated using the QD-nanobeads as fluorescent reporters. This nanoparticle-polymer self-assembly technology is capable of producing a variety of nanostructures and is expected to open new opportunities in nanoparticle-based ultrasensitive detection and imaging.
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