4.8 Article

Evolution of Solid Phase Homochirality for a Proteinogenic Amino Acid

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 46, Pages 15274-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja8074506

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Funding

  1. AstraZeneca
  2. Royal Society Wolfson Research Merit Award

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The inexorable evolution of solid-phase single chirality is demonstrated for the first time for a proteinogenic amino acid. Enantioenrichment is observed both under attrition-enhanced conditions and without the aid of particle grinding. Differences in the form of the conversion profiles for the process under the two sets of conditions provide suggestions concerning the mechanism of the transformation.

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