Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 21, Pages 6662-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja0777990
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Funding
- NCRR NIH HHS [S10 RR015685, S10 RR15685-01, S10 RR015685-01] Funding Source: Medline
- NIBIB NIH HHS [R01 EB005866, R01 EB005866-01, 1R01 EB005866-01] Funding Source: Medline
- NINDS NIH HHS [P50 NS054287, P50 NS054287-019002, 1P50 NS054287-01] Funding Source: Medline
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We have prepared a series of molecular multimeric MR contrast agents for cell labeling that are easy to synthesize, relatively low molecular weight, and biocompatible. The relaxivities of the agents range from 17 to 85 mM(-1)s(-1). Cellular uptake is concentration dependent and viability is excellent. MR images of cell pellets reveal a marked increase in observed signal intensity.
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