Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 14, Pages 4978-4983Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja710922h
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM064451, R01 GM064451-07, GM-64451] Funding Source: Medline
Ask authors/readers for more resources
The nickel-catalyzed enantioselective addition of allylboronic acid pinacol ester, allyIB(pin), is described. This reaction is highly effective with dialkylidene ketones and favors the allylation of the benzylidene site in nonsymmetric substrates. The reaction appears to proceed by conversion of the dialkylidene ketone substrate to an unsaturated pi-allyl complex (1), followed by reductive elimination. Enantioselectivities range from 91 to 94% ee for a range of substrates when chiral ligand 14 is employed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available