Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 47, Pages 15786-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja8071034
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Funding
- Alexander von Humboldt Foundation
- Max-Planck-Society, the DFG [SPP1179]
- AstraZeneca
- Fond der Chemischen Industrie (
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A highly enantioselective Bronsted acid catalyzed direct synthesis of cyclic aminals from aldehydes has been developed. The methodology has been applied to the first asymmetric synthesis of several anti hypertensive aminal drugs including (R)-Thiabutazide.
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