4.8 Article

A Diazirine-Based Nucleoside Analogue for Efficient DNA Interstrand Photocross-Linking

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 44, Pages 14398-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja805445j

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Funding

  1. W. M. Keck Foundation
  2. Amold and Mabel Beckman Foundation
  3. Research Corporation
  4. Camille Dreyfus Teacher Scholar Award

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A diazirine-based nucleoside analogue (DBN) efficiently forms DNA interstand cross-linking under near-UV irradiation. This new base analogue may find broad applications in biotechnology and phototherapy.

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