Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 21, Pages 6710-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja801976h
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Funding
- NCI NIH HHS [CA35635, R01 CA035635] Funding Source: Medline
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The effects of substitution of O-6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure.
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