Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 3, Pages 821-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja077245x
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM074756, R01 GM074756-02] Funding Source: Medline
Ask authors/readers for more resources
A 28 residue 'retro' beta-peptide has been designed to self-assemble as a tetramer, successfully recapitulating the octameric beta-peptide bundle complex Zwit-1F. Z28, the largest beta-peptide synthesized to date, was achieved in a linear, microwave-assisted synthesis in 19% isolated yield and high purity. Z28 forms the expected tetrameric complex and is more stable and cooperative in its folding than Zwit-1F. The successful design and synthesis of Z28 is an important step toward true R amino acid proteins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available