4.8 Article

Versatile Pd(II)-Catalyzed C-H Activation/Aryl-Aryl Coupling of Benzoic and Phenyl Acetic Acids

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 52, Pages 17676-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja806681z

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Funding

  1. National Institutes of Health [1 R01 GM08401901A1]
  2. A. P. Sloan Foundation

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The use of aryltrifluoroborates as coupling partners and O-2 as the oxidant substantially improves the scope and practicality of the Pd-catalyzed C-H activation/C-C coupling reaction. The newly discovered protocol made possible, for the first time, the orthocoupling of electron-deficient arenes and phenyl acetic acids With organometallic reagents.

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