4.8 Article

Enantioselective Total Syntheses of Trichodermamides A and B

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 51, Pages 17236-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja807011b

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Funding

  1. NSF [CHEM-0515443]

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Starting from commercially available (-)-quinic acid, the enantioselective total syntheses of trichodermamides A and B were achieved. The key reactions involve the stereoselective construction of the oxazine ring via an intramolecular epoxide ring opening reaction and an EDCl-assisted peptide coupling reaction,

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