Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 24, Pages 7542-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja802003h
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Funding
- NCI NIH HHS [R21CA121842, R21 CA121842, R21 CA128529-01, U54CA119367, 1R21CA12859-01, U54 CA119367] Funding Source: Medline
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We report a direct synthesis of ultrasmall c(RGDyK) peptide-coated Fe3O4 NPS (< 10 nm in hydrodynamic diameter) and demonstrate their in vivo tumor-specific targeting capability. The Fe3O4 NPs are synthesized by thermal decomposition fo iron pentacarbonyl in the presence of 4-methylcatechol (4-MC), and the peptide is coupled to nanoparticles through 4-MC via Mannich reaction. The c(RGDyK)-MC-Fe3O4 NPs have an overall diameter of similar to 8.4 nm and are stable in physiological conditions. When administered intravenously, these c(RGDyK)-MC-Fe3O4 NPs accumulate preferentially in the integrin alpha(v)beta(3)-rich tumor area, which are readily tracked by MRI.
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