4.8 Article

Fast and highly regioselective allylation of indole and pyrrole compounds by allyl alcohols using Ru-sulfonate catalysts

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 130, Issue 35, Pages 11604-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja804379k

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Funding

  1. Swiss National Science Foundation
  2. ETH Zurich

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New Ru-sulfonate catalysts have been synthesized and shown to very rapidly allylate indole and pyrrole compounds using allyl alcohols as substrates. The observed regioselectivity is exceptionally high (up to 100% of the branched isomer). Density functional theory calculations explain these results.

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