Journal
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Volume 18, Issue 9, Pages 576-579Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.5435/00124635-201009000-00009
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For this technology overview, the tools of evidence-based medicine were used to summarize information on the effectiveness and clinical outcomes related to the usage of bone void fillers-specifically, synthetic graft materials. Comprehensive literature searches were conducted to address five key questions, which the task force that prepared the report posed as follows. Question 1 addressed the use of synthetic bone void fillers alone. Question 2 was designed to determine whether synthetic bone void fillers could successfully serve as graft extenders and eliminate the need for iliac crest bone graft. Questions 3, 4, and 5 addressed the use of allografts as a comparison with synthetic fillers because clinical results with allografts are perceived as being much closer to autografts in these areas of the spine.
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