Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 70, Issue 3, Pages 517-524Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2013.10.044
Keywords
comorbidity; liver disease; metabolic syndrome; nonalcoholic fatty liver disease; psoriasis
Categories
Funding
- Netherlands Organization for Scientific Research
- Netherlands Organization for Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture, and Science
- Ministry of Health, Welfare, and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- Foundation for Liver Research (SLO), Rotterdam, The Netherlands
- Erasmus MC University Medical Center
- Erasmus University Rotterdam
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Background: Recent case-control studies observed an increased prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with psoriasis, which is relevant in selecting optimal psoriasis treatment. Objective: We sought to compare the prevalence of NAFLD in people with psoriasis and those without psoriasis. Methods: This large prospective population-based cohort study (part of the Rotterdam Study) enrolled elderly participants (>55 years). NAFLD was diagnosed as fatty liver on ultrasonography in the absence of other liver diseases. Participants with psoriasis were identified using a validated algorithm. Multivariable logistic regression model was used to assess whether psoriasis was associated with NAFLD after adjusting for demographic, lifestyle characteristics, and laboratory findings. Results: In total, 2292 participants were included (mean age 76.2 +/- 6.0 years; 58.7% female; mean body mass index 27.4 +/- 4.2kg/m(2)) of whom 118 (5.1%) had psoriasis. The prevalence of NAFLD was 46.2% in patients with psoriasis compared with 33.3% for the reference group without psoriasis (P = .005). Psoriasis was significantly associated with NAFLD; after adjustment for alcohol consumption, pack-years and smoking status, presence of metabolic syndrome, and alanine aminotransferase, psoriasis remained a significant predictor of NAFLD (adjusted odds ratio 1.7, 95% confidence interval 1.1-2.6). Limitations: This was a cross-sectional study. Conclusion: Elderly participants with psoriasis are 70% more likely to have NAFLD than those without psoriasis independent of common NAFLD risk factors.
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