Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 71, Issue 2, Pages 366-375Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2014.03.031
Keywords
anorectal mucosal melanoma; C-KIT inhibitors; clinical characteristics; mucosal melanoma of the head and neck; pathology; urinary tract melanoma; vulvar and vaginal mucosal melanoma; treatment
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Funding
- Dermatology Foundation
- Char and Chuck Fowler Family Foundation
- Elsevier
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Mucosal melanomas are aggressive cancers of mucosal surfaces with clinical and pathologic characteristics distinct from cutaneous melanomas, warranting different staging systems and treatment approaches. Surgical resection is performed frequently for the primary tumor, although the utility of lymph node surgery and radiation therapy is not established. Therapies targeted against C-KIT activating mutations, identified in many mucosal melanomas, are emerging as promising treatments.
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