Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 68, Issue 5, Pages 834-853Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2012.11.002
Keywords
anakinra; autoinflammation; common dermatoses; inflammasomes; interleukin-1 beta; periodic fevers
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Funding
- Intramural NIH HHS [ZID BC011317] Funding Source: Medline
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Autoinflammation is characterized by aberrant regulation of the innate immune system and often manifests as periodic fevers and systemic inflammation involving multiple organs, including the skin. Mutations leading to abnormal behavior or activity of the interleukin 1 beta (IL-1 beta)-processing inflammasome complex have been found in several rare autoinflammatory syndromes, for which anticytokine therapy such as IL-1 or tumor necrosis factor-alfa inhibition may be effective. It is becoming clear that features of autoinflammation also affect common dermatoses, some of which were previously thought to be solely autoimmune in origin (eg, vitiligo, systemic lupus erythematosus). Recognizing the pathogenetic role of autoinflammation can open up new avenues for the targeted treatment of complex, inflammatory dermatoses. (J Am Acad Dermatol 2013;68:834-53.)
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