Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 67, Issue 5, Pages 1013-1024Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2012.02.009
Keywords
antioxidants; free radicals; photoaging; photoprotection; reactive oxygen species; sunscreen
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Free radicals have long been studied as a contributor to aging and disease processes. Endogenous production of radicals from cellular metabolism and exogenous sources from ultraviolet radiation and pollution can damage the skin on the cellular and tissue levels. Although the body possesses an elegant defense system to prevent radical damage, this innate system can be overwhelmed and lead to a state of oxidative stress or immunosuppression, and can even trigger carcinogenesis. Topical supplementation of antioxidants can provide additional protection to neutralize reactive oxygen species from both endogenous and exogenous sources. This review will discuss our current understanding of the mechanisms of free radical damage and evaluate the potential benefit of topical antioxidants in sunscreens and skin care products. (J Am Acad Dermatol 2012;67:1013-24.)
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