Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 67, Issue 5, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2012.05.044
Keywords
25(OH)D levels; cholecalciferol; supplements; vitamin D; ultraviolet radiation
Categories
Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [K23 AR 051037-01, K23 AR 056736-01]
- Damon Runyon Clinical Investigator Award
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Skin cancer is the most common cancer in the United States. Exposure to ultraviolet radiation is a known risk factor for skin cancer but is also the principal means by which the body obtains vitamin D. Several studies have suggested that vitamin D plays a protective role in a variety of internal malignancies. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar protective effect. These noncalcemic actions of vitamin D have called into question whether the current recommended intake of vitamin D is too low for optimal health and cancer prevention. Part I will review the role of vitamin D in the epidermis; part II will review the role of vitamin D in keratinocyte-derived tumors to help frame the discussion on the possible role of vitamin D in the prevention of skin cancer. (J Am Acad Dermatol 2012;67:803.e1-12.)
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