Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 66, Issue 4, Pages 515-534Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2011.11.960
Keywords
fasciitis; fibrosis; graft-versus-host disease; hematopoietic cell transplantation
Categories
Funding
- National Cancer Institute, Center for Cancer Research
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Approximately 25,000 allogeneic hematopoietic cell transplants are performed worldwide each year for a variety of malignant and non-malignant conditions. Graft-versus-host disease represents one of the most frequent complications and is a major source of long-term morbidity and mortality. Whereas acute graft-versus-host disease is induced by recognition of host tissues as foreign by immunocompetent donor cells, the pathogenesis of chronic graft-versus-host disease is not as well understood, and continues to be a major treatment challenge. Part I of this two-part series reviews the epidemiologic factors, classification, pathogenesis, and clinical manifestations of acute and chronic graft-versus-host disease. Part II discusses the topical, physical, and systemic treatment options available to patients with graft-versus-host disease. (J Am Acad Dermatol 2012;66:515.e1-18.)
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