Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 65, Issue 2, Pages 263-279Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2010.11.063
Keywords
immunosuppression; nonmelanoma skin cancer; organ transplant recipients; radiotherapy; sentinel lymph node biopsy
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The management of skin cancer in solid organ transplant recipients is a challenge to both the dermatologist and transplant physician. Part II of this continuing medical education review offers an approach to the management of this increasing problem. The importance of specialty dermatology clinics providing access to transplant patients, frequent skin cancer screening, patient education, and multidisciplinary care is discussed. The management of low risk squamous cell carcinoma with topical therapies, photodynamic therapy, systemic retinoids, and capecitabine is reviewed. Revision of immunosuppression in the management of high-risk patients is discussed in association with the potential role of sentinel lymph node biopsy for aggressive disease. Finally, management of in-transit and metastatic squamous cell carcinoma is reviewed, with a discussion of the role of more recent innovative therapies, including epidermal growth factor receptor inhibitors in advanced squamous cell carcinoma in solid organ transplant recipients. (J Am Acad Dermatol 2011;65:263-79.)
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