Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 60, Issue 5, Pages 863-868Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2008.09.053
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- Deutsche Forschungsgemeinschaft [SFB 773]
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Melanoma is highly resistant to chemotherapy. in melanoma, the PI3K-AKT-mTOR signaling pathway is constitutively activated through multiple mechanisms. Several experimental studies suggest that targeting the POK-AKT-mTOR signaling pathway is a promising strategy to overcome chemoresistance. This is the first report describing a chemosensitizing effect of mTOR inhibition in patients with melanoma. We report two cases of patients with metastatic melanoma who showed significant remission after combination of carboplatin and paclitaxel with the mTOR inhibitor sirolimus. Our case report, together with the literature discussed, Suggests that mTOR inhibition possibly enhances the sensitivity of melanoma cells to chemotherapy and should prompt in-depth and clinical investigation. (J Am Acad Dermatol 2009;60:863-8.)
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