Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 61, Issue 4, Pages 652-665Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2009.02.039
Keywords
extracorporeal photopheresis; cutaneous T-cell lymphoma; mycosis fungoides; Sezary syndrome; systemic sclerosis; graft-versus-host disease; solid organ transplant; cardiac transplant; lung transplant; bronchiolitis obliterans; bronchiolitis obliterans syndrome; liver transplant; renal transplant; Crohn disease; atopic dermatitis; lichen planus; contact hypersensitivity mouse model; T-cell clonality; bone marrow transplant
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- Therakos
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Extracorporeal photopheresis (ECP) is a leukapheresis-based therapy that Uses 8-methoxypsoralen and ultraviolet A irradiation. Used alone or in combination with biological agents, ECP is an established and effective therapy for advanced cutaneous T-cell lymphoma. ECP has also shown promising efficacy, in a number of other sex,ere and difficult-to-treat conditions, including systemic sclerosis, graft-versus-host disease, prevention and treatment of rejection in solid organ transplantation, and Crohn disease. Furthermore, the use of ECP in some of these conditions may allow a significant reduction in the use of systemic steroids and other immunosuppressants, reducing long-term morbidity and mortality. The accumulated experience shows ECP to be well tolerated, with no clinically significant side effects. Progress is also being made in the search for understanding of the mechanisms of action of ECP, which will ultimately facilitate improvements in the use of this therapy. (J Am Acad Dermatol 2009;61:652-65.)
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