Journal
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
Volume 50, Issue 9, Pages 938-948Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jaac.2011.06.011
Keywords
obsessive-compulsive disorder; frontal-striatal-thalamic; medial frontal cortex; resting state connectivity; development
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Funding
- National Institute of Mental Health [R01 MH071821, K23MH082176, F32 MH082573]
- National Institute of Neurological Disorders and Stroke [R01-NS052514]
- National Alliance for Research on Schizophrenia and Depression
- Dana Foundation
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Pediatric obsessive-compulsive disorder is characterized by abnormalities of frontal striatal thalamic circuitry that appear near illness onset and persist over its course. Distinct frontal-striatal-thalamic loops through cortical centers for cognitive control (anterior cingulate cortex) and emotion processing (ventral medial frontal cortex) follow unique maturational trajectories, and altered connectivity within distinct loops may be differentially associated with OCD at specific stages of development. Method: Altered development of striatal and thalamic connectivity to medial frontal cortex was tested in 60 OCD patients compared with 61 healthy control subjects at child, adolescent, and adult stages of development, using resting-state functional connectivity MRI. Results: OCD in the youngest patients was associated with reduced connectivity of dorsal striatum and medial dorsal thalamus to rostral and dorsal anterior cingulate cortex, respectively. Increased connectivity of dorsal striatum to ventral medial frontal cortex was observed in patients at all developmental stages. In child patients, reduced connectivity between dorsal striatum and rostral anterior cingulate cortex correlated with OCD severity. Conclusions: Frontal striatal thalamic loops involved in cognitive control are hypoconnected in young patients near illness onset, whereas loops implicated in emotion processing are hyperconnected throughout the illness. J. Am. Acad. Child Adolesc. Psychiatry, 2011;50(9):938-948.
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