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JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
Volume 129, Issue 4, Pages 1729-1739Publisher
ACOUSTICAL SOC AMER AMER INST PHYSICS
DOI: 10.1121/1.3505116
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Oscillating phospholipid-coated ultrasound contrast agent microbubbles display a so-called compression-only behavior, where it is observed that the bubbles compress efficiently while their expansion is suppressed. Here, a theoretical understanding of the source of this nonlinear behavior is provided through a weakly nonlinear analysis of the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499-3505 (2005)]. It is shown that the radial dynamics of the bubble can be considered as a superposition of a linear response at the fundamental driving frequency and a second-order nonlinear low-frequency response that describes the negative offset of the mean bubble radius. The analytical solution deduced from the weakly nonlinear analysis shows that the compression-only behavior results from a rapid change of the shell elasticity with bubble radius. In addition, the radial dynamics of single phospholipid-coated microbubbles was recorded as a function of both the amplitude and the frequency of the driving pressure pulse. The comparison between the experimental data and the theory shows that the magnitude of compression-only behavior is mainly determined by the initial phospholipids concentration on the bubble surface, which slightly varies from bubble to bubble. (C) 2011 Acoustical Society of America. [DOI:10.1121/ 1.3505116]
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