Journal
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
Volume 128, Issue 5, Pages EL310-EL315Publisher
ACOUSTICAL SOC AMER AMER INST PHYSICS
DOI: 10.1121/1.3496388
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Funding
- U.K.'s Engineering and Physical Sciences Research Council [EP/F011547/1]
- EPSRC [EP/F011547/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F011547/1] Funding Source: researchfish
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Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring. (C) 2010 Acoustical Society of America
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