Journal
PLASTIC AND RECONSTRUCTIVE SURGERY
Volume 135, Issue 3, Pages 808-816Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PRS.0000000000000963
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Funding
- National Institutes of Health [U01 HL099776, R01 DE021683-01, R21 DE02423001]
- Oak Foundation
- Gunn/Olivier fund
- Hagey Laboratory for Pediatric Regenerative Medicine
- American College of Surgeons Franklin H. Martin Faculty Research Fellowship
- Stanford University Child Health Research Institute Faculty Scholar Award
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Bone is a dynamic tissue, with a range of diverse functions, including locomotion, protection of internal organs, and hematopoiesis. Optimum treatment of fractures and/or bone defects requires knowledge of the complex cellular interactions involved with bone healing and remodeling. Emerging data have underscored the importance of osteoclasts in this process, playing a key role both in normal bone turnover and in facilitating bone regeneration. In this review, the authors discuss the basic principles of osteoclast biology, including its cellular origins, its function, and key regulatory mechanisms, in addition to conditions that arise when osteoclast function is altered.
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