Journal
JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY
Volume 23, Issue 6, Pages 1221-1230Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11424-010-8467-0
Keywords
Basic infection reproduction number; clinical data simulation; equilibrium point; global stability; HBV infection
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Funding
- National Natural Science Foundations of China [60674059]
- 11th 5-Year Plan Key Research Project of China [2004BA721A03]
- China National Key Special Project for the Preventions and Cures of Important Infectious Diseases [2008ZX10005-006]
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In this paper, the authors first show that if R-0 <= 1, the infection free steady state is globally attractive by using approaches different from those given by Min, et al.(2008). Then the authors prove that if R-0 > 1, the endemic steady state is also globally attractive. Finally, based on a patient's clinical HBV DNA data of anti-HBV infection with drug lamivudine, the authors establish an ABVIM. The numerical simulations of the ABVIM are good in agreement with the clinical data.
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