Journal
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
Volume 67, Issue 10, Pages 992-1000Publisher
SOC SYNTHETIC ORGANIC CHEM JPN
DOI: 10.5059/yukigoseikyokaishi.67.992
Keywords
heteroaromatic compounds; trifluoromethyl group; pyridines; synthesis; applications; biologically active molecules
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Heteroaromatic compounds are widely distributed in nature and often found in numerous biologically active natural products, agrochemicals, drugs, dyes, polymers, etc. because they usually have various chemical and physicochemical properties. In particular, pyridines are one of the most important heteroaromatic compounds and thus widely applied as biologically active compounds and organic materials. Trifluoromethyl-containing heteroaromatic compounds often have extremely unique properties and therefore have been studied during the last several decades. In fact, some of such compounds are currently widely utilized as commercialized agrochemicals, drugs etc. as well as drug candidates under development. This review introduces synthesis of several trifluoromethyl-containing pyridines and their applications to biologically active molecules.
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