Journal
JOURNAL OF SYNCHROTRON RADIATION
Volume 19, Issue -, Pages 875-886Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S090904951203943X
Keywords
X-ray absorption spectroscopy; extended X-ray absorption fine structure; X-ray absorption near edge; photo-reduction; metalloproteins; metalloenzymes
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes for Health Research (CIHR)
- Saskatchewan Health Research Foundation (SHRF)
- CIHR
- SHRF
- CIHR/Heart and Stroke Foundation of Canada Team in Synchrotron Medical Imaging (Nichol, PI)
- PrioNet Canada
- DOE Office of Biological and Environmental Research
- National Institutes of Health, National Center for Research Resources [5P41RR001209]
- National Institute of General Medical Sciences [8 P41 GM103393]
- Australian Research Council (ARC) [DP0208409, DP0774173, DP0984722, LE0989759]
- ARC Linkage Infrastructure, Equipment and Facilities (LIEF) Program grant [LE0346515]
- International Synchrotron Access Program (ISAP) grants of the Australian Synchrotron
- ISAP
- High Energy Accelerator Research Organization (KEK) in Tsukuba, Japan
- Centre National de la Recherche Scientifique (CNRS)
- Australian Research Council [DP0208409, LE0346515, DP0774173] Funding Source: Australian Research Council
Ask authors/readers for more resources
As synchrotron light sources and optics deliver greater photon flux on samples, X-ray-induced photo-chemistry is increasingly encountered in X-ray absorption spectroscopy (XAS) experiments. The resulting problems are particularly pronounced for biological XAS experiments. This is because biological samples are very often quite dilute and therefore require signal averaging to achieve adequate signal-to-noise ratios, with correspondingly greater exposures to the X-ray beam. This paper reviews the origins of photo-reduction and photo-oxidation, the impact that they can have on active site structure, and the methods that can be used to provide relief from X-ray-induced photo-chemical artifacts.
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