Journal
JOURNAL OF SYNCHROTRON RADIATION
Volume 16, Issue -, Pages 57-62Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S0909049508031853
Keywords
X-ray fluorescent CT; fluorescent X-ray; molecular imaging; cerebral perfusion; IMP
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Funding
- Japanese Ministry of Education, Science and Culture [19390313]
- National Laboratory for High Energy Physics [2007G643]
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Using X-ray fluorescent computed tomography (XFCT), the in vivo and ex vivo cerebral distribution of a stable-iodine-labeled cerebral perfusion agent, iodoamphetamine analog (I-127-IMP), has been recorded in the brains of mice. In vivo cerebral perfusion in the cortex, hippocampus and thalamus was depicted at 0.5 mm in-plane spatial resolution. Ex vivo XFCT images at 0.25 mm in-plane spatial resolution allowed the visualisation of the detailed structures of these regions. The quality of the XFCT image of the hippocampus was comparable with the I-125-IMP autoradiogram. These results highlight the sensitivity of XFCT and its considerable potential to evaluate cerebral perfusion in small animals without using radioactive agents.
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