Journal
JOURNAL OF SURGICAL RESEARCH
Volume 147, Issue 1, Pages 153-159Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2007.06.015
Keywords
liver; ischemia-reperfusion; IR injury; nitric oxide; NO; iNOS; adenosine; cytokines; endothelial and Kupffer cells; ROS
Categories
Funding
- NIDDK NIH HHS [R01 DK062313-04] Funding Source: Medline
- NIGMS NIH HHS [R01 GM052021-13] Funding Source: Medline
Ask authors/readers for more resources
Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma. The signaling events contributing to local hepatocellular damage are diverse and complex and involve the interaction between hepatocytes, sinusoidal endothelial cells, Kupffer cells, as well as infiltrating neutrophils, macrophages, and platelets. Signaling mediators include cytokines, reactive oxygen and nitrogen species, calcium, complement, and several transcription factors. The purpose of this review article was to summarize the factors that contribute to the pathophysiology of hepatic ischemia-reperfusion injury. (C) 2008 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available