Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 118, Issue 2, Pages 344-355Publisher
WILEY
DOI: 10.1002/jso.25149
Keywords
indocyanine green (ICG); intraoperative fluorescence imaging (IFI); near-infrared (NIR) fluorescence imaging; OTL38; thoracic surgery
Funding
- NCI NIH HHS [R01 CA193556] Funding Source: Medline
- NIH Blueprint for Neuroscience Research [R01 CA193556] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA193556] Funding Source: NIH RePORTER
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Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow((R))) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.
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