Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 108, Issue 5, Pages 289-293Publisher
WILEY-BLACKWELL
DOI: 10.1002/jso.23400
Keywords
lung cancer; screening; computerized tomogram; CT scan; over-diagnosis; non-lethal lung cancer; in situ adenocarcinoma of the lung; lung cancer-specific mortality; survival; tumor volume doubling time
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Overestimation of the frequency and impact of over-diagnosis bias in lung cancer screening has contributed to long delays in implementation of lung cancer screening programs. Literature review reveals little evidence of substantial numbers of over-diagnosed non-lethal lung cancer. There is now strong evidence that lung cancers that would not cause symptoms or kill during normal anticipated survival are uncommon and mostly limited to in situ adenocarcinomas, identifiable as CT non-solid nodules. Prevention of overtreatment is possible within well-constructed diagnostic algorithms. J. Surg. Oncol. 2013 108:289-293. (c) 2013 Wiley Periodicals, Inc.
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