Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 109, Issue 2, Pages 95-97Publisher
WILEY-BLACKWELL
DOI: 10.1002/jso.23448
Keywords
neutrophil-to-lymphocyte ratio; hepatocellular carcinoma; inflammation
Funding
- NCI NIH HHS [R25 CA132822] Funding Source: Medline
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Background and ObjectivesNeutrophil-to-lymphocyte ratio (NLR) is simple, inexpensive, and has been proposed to be predictive in hepatocellular carcinoma (HCC) in Europe and Asia. We aimed to evaluate whether NLR at presentation in a Western center provides any prognostic value compared to other common prognostic scores. MethodsNLR was calculated for 75 consecutive patients at presentation with HCC and regression models were used to analyze its value for predicting treatment strategy and short-term survival with Child-Pugh and Model for End Stage Liver Disease (MELD). ResultsNLR was not predictive of future treatment regimens with hepatectomy, liver transplant, or transarterial chemoembolization (TACE; odds ratio [OR]: 0.85, 95% confidence interval [CI]: 0.71-1.02, P=0.079) as compared the predictive value of MELD (OR: 0.81, CI: 0.72-0.93, P=0.002) or Child-Pugh (OR: 0.48, CI: 0.34-0.69, P<0.001). Adding additional adjustment for treatment, NLR did not correlate with short-term overall survival (hazard ratio [HR]: 1.09, CI: 0.95-1.24, P=0.227). MELD also did not correlate with overall survival (HR: 1.04, CI: 0.96-1.13, P=0.357) whereas Child-Pugh (HR: 1.56, CI: 1.10-2.19, P=0.011) was predictive. ConclusionsThis study does not support the prognostic value of NLR to guide therapy for HCC in a Western center, whereas MELD and Child-Pugh score were more predictive. J. Surg. Oncol. 2014 109:95-97. (c) 2013 Wiley Periodicals, Inc.
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