Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 106, Issue 1, Pages 41-45Publisher
WILEY
DOI: 10.1002/jso.23045
Keywords
sentinel node biopsy; indocyanine green; false negative; radioisotope
Funding
- National Cancer Center [23-A-22]
- Grants-in-Aid for Scientific Research [24659519] Funding Source: KAKEN
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Background and Objectives Although sentinel lymph node (SLN) biopsy using radioisotope (RI) and blue dye (BD) achieved a high detection rate, approximately 5% of melanomas with negative SLNs develop nodal metastasis. We tested a new lymphatic navigation method using indocyanine green fluorescence imaging (ICG-FI) to detect such occult SLNs. Methods Thirty-four skin cancer patients received SLN biopsy with the following three methods: RI (99Tc-tin colloid), BD (2% patent blue), and ICG (0.5% indocyanine green). Lymph nodes detected by any of the three methods were counted as SLNs. Results ICG-FI detected more SLNs in 8 out of the 34 cases (24%). The average numbers of SLNs detected by ICG-FI, RI, and BD were 2.18, 1.76, and 1.73, respectively. Interestingly, ICG-FI not only detected more SLNs in one basin (ICG-FI: 1.64, RI: 1.50, and BD: 1.51 SLNs per basin), but also detected additional SLNs in other basins (ICG-FI: 1.32, RI: 1.18, and BD: 1.15 basins per case). Conclusion ICG-FI detected SLNs more efficiently than did the conventional methods, and these occult SLNs may offer an explanation for some false-negative cases. We recommend using ICG-FI in addition to a conventional method to reduce the risk of overlooking these occult SLNs. J. Surg. Oncol. 2012; 106:4145. (C) 2012 Wiley Periodicals, Inc.
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