Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 105, Issue 6, Pages 542-547Publisher
WILEY-BLACKWELL
DOI: 10.1002/jso.22151
Keywords
Beclin 1; gastric carcinoma; immunohistochemistry; metastasis; prognosis
Funding
- Key Project of Science and Technology of Guangdong Province [2008B030301079]
- National Nature Science Foundation of China [30972882]
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Background and Objectives Beclin 1 plays a critical role in the regulation of autophagy, apoptosis, differentiation and the development and progression of cancer. The clinicopathological significance of Beclin 1 expression in patients with gastric carcinoma (GC) has not been yet elucidated. Methods: Immunohistochemistry (IHC) was performed to investigate the Beclin 1 expression in GCs and normal mucosal tissues. Receiver operating characteristic curve analysis, spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model were used to analyze the data. Results: The highly expressed Beclin 1 was observed in 90/155 (58.1%) of GCs, in 24/60 (40.0%) adjacent mucosal tissues and in 13/30 (43.3%) of normal gastric mucosa tissues (P 0.036). Decreased expression of Beclin 1 in cancer cells was significantly correlated with poor differentiation, nodal and distant metastasis, advanced TNM stage, and tumor relapse. More importantly, Decreased expression of Beclin 1 was associated with shorter survival as evidenced by univariate and multivariate analysis. Conclusions: Our findings provide a basis for the concept that decreased expression of Beclin 1 in GC may be important in the acquisition of a metastatic phenotype, suggesting that decreased Beclin 1 expression, as examined by IHC, is an independent biomarker for poor prognosis of patients with GC. J. Surg. Oncol. 2012; 105: 542-547. (C) 2011 Wiley Periodicals, Inc.
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