Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 105, Issue 8, Pages 793-799Publisher
WILEY
DOI: 10.1002/jso.23009
Keywords
China; FOLFOX; gastric cancer; neoadjuvant chemotherapy; oxaliplatin; surgery
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Background Although the role of peri-operative chemotherapy is established in the treatment of locally advanced gastric cancer, the optimal regime remains to be determined. FOLFOX has been used in palliative setting with good response rates but its role in a neoadjuvant setting is not well established. Methods This is a prospective non-randomized study comparing peri-operative FOLFOX versus adjuvant FOLFOX in patients with resectable locally advanced gastric cancer. Response to chemotherapy was assessed according to WHO criteria and pathological changes. KaplanMeier log rank test was used to calculate and compare survival differences. Results There were 73 patients (neoadjuvant?=?36). Complete and partial response was observed in 2 (6%) and 21 (64%) patients, respectively. Four-year overall survival (OS) in the neoadjuvant arm was 78% versus 51% in the adjuvant arm (P?=?0.031). Subgroup analysis found R0 resection (86% vs. 55%, P?=?0.011) and patients with proximal cancers (87% vs. 14%, P?
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