Journal
JOURNAL OF SUPERCRITICAL FLUIDS
Volume 80, Issue -, Pages 38-43Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2013.03.015
Keywords
Solubility; Supercritical carbon dioxide; Piroxicam; Correlation; Extrapolation; Semi-empirical correlations
Categories
Ask authors/readers for more resources
Since the knowledge of pharmaceutical solubilities in the supercritical carbon dioxide is one of the first essential necessities for designing the supercritical carbon dioxide-based processes, solubility of piroxicam a non-steroidal anti-inflammatory drug was experimentally measured. In this regard, a static method coupled with gravimetric method was used to measure the solubility of piroxicam in the supercritical carbon dioxide in temperature and pressure range of 308.15-338.15 K and 16-40 MPa, respectively. The obtained solubility data were in the range of 1.17 x 10(-5) and 5.12 x 10(-4) based on the mole fraction (mole piroxicam/(mole piroxicam + mole CO2)) then modeled using four different density based correlations namely Bartle et al., Mendez-Santiago-Teja, Chrastil and Kumar and Johnston models. The results of error analysis revealed that the used correlations were potential to correlate the solubility of piroxicam with minimum and maximum average absolute relative deviation percents (AARD%) of 14.4% and 15.2%, respectively. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available