Journal
PLANTA MEDICA
Volume 81, Issue 8, Pages 648-654Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1546017
Keywords
olive leaf constituents; oxidative stress; LDL oxidation; anti-atherosclerotic effects; anti-ischemic effects; Olea europaea; Oleaceae
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The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effects. The pathogenesis of certain common diseases, including those of the cardiovascular system, involves oxidative stress and tissue inflammation. Olive polyphenolic compounds, such as oleuropein, hydroxytyrosol, or tyrosol, possess antioxidant, anti-inflammatory, antiatherosclerotic, anti-ischemic, and hypolipidemic effects on the myocardium as demonstrated by various in vitro and in vivo studies. In this review article, we summarize the current knowledge on the role of the olive leaf constituents in the prevention of cardiac dysfunction and highlight future perspectives in their use as cardioprotective agents in therapeutics.
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