Journal
JOURNAL OF SULFUR CHEMISTRY
Volume 34, Issue 6, Pages 684-691Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17415993.2013.778259
Keywords
sulfenic acids; disulfides; sulfoxides; cytotoxicity; hemolytic activity
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Funding
- Italian Ministry for the University and Research (MIUR) [PON01_01499, PRIN 20109Z2XRJ_010]
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This article examines the effects of some glycoconjugated disulfides and sulfoxides on red blood cells (RBCs). Compounds under study show sugar units connected directly or through a benzene platform, and have been obtained following synthetic pathways based on the sulfenic acid chemistry. In order to evaluate the relationship between the structural features of the thioglycoconjugates under investigation and their potential biological activity, we were interested in assessing both the cytotoxicity and hemolytic activity produced on human RBCs by overnight exposition to the thioglycoconjugates. The absence of both cytotoxic effect and hemolysis produced by the tested compounds on erythrocytes supports the rational design of hemocompatible molecules for biomedical applications. [GRAPHICS] .
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