Journal
JOURNAL OF STRUCTURAL BIOLOGY
Volume 161, Issue 1, Pages 92-100Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jsb.2007.09.017
Keywords
single-particle electron cryo-microscopy; beam-induced movement; radiation damage; dose-rate effect; high-resolution EM
Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM062580] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [P01 GM062580-050002] Funding Source: Medline
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A low beam intensity, low electron dose imaging method has been developed for single-particle electron cryo-microscopy (cryo-EM). Experiments indicate that the new technique can reduce beam-induced specimen movement and secondary radiolytic effects, such as bubbling. The improvement in image quality, especially for multiple-exposure data collection, will help single-particle cryo-EM to reach higher resolution. (c) 2007 Elsevier Inc. All rights reserved.
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