Journal
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 143, Issue -, Pages 61-71Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2014.01.016
Keywords
Menopause; Hormone replacement therapy; Phytoestrogens; Toxicology
Funding
- Portuguese Foundation for Science and Technology (FCT) [PTDC/AGR-ALI/108326/2008, PEst-C/SAU/LA0001/2013-2014]
- FCT [SFRH/BD/33892/2009, SFRH/BD/76086/2011, SFRH/BPD/31549/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/33892/2009, SFRH/BD/76086/2011, SFRH/BPD/31549/2006] Funding Source: FCT
Ask authors/readers for more resources
Menopause is characterized by an altered hormonal status and by a decrease in life quality due to the appearance of uncomfortable symptoms. Nowadays, with increasing life span, women spend one-third of their lifetime under menopause. Understanding menopause-associated pathophysiology and developing new strategies to improve the treatment of menopausal-associated symptoms is an important topic in the clinic. This review describes physiological and hormone alterations observed during menopause and therapeutic strategies used during this period. We critically address the benefits and doubts associated with estrogen/progesterone-based hormone replacement therapy (HRT) and discuss the use of phytoestrogens (PEs) as a possible alternative. These relevant plant-derived compounds have structural similarities to estradiol, interacting with cell proteins and organelles, presenting several advantages and disadvantages versus traditional HRT in the context of menopause. However, a better assessment of PEs safety/efficacy would warrant a possible widespread clinical use. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available